Genetics & Molecular Biology explores how genetic information is inherited, expressed, and regulated at the molecular level. This category integrates classical genetics with modern molecular biology to explain the mechanisms governing heredity, variation, and gene expression , making it suitable for Class 11–12 students , NEET aspirants , and undergraduate learners .
In this section, you will study:
Basic concepts of genetics and heredity
Mendelian and non-Mendelian inheritance patterns
Molecular structure of DNA and RNA
DNA replication, transcription, and translation
Gene regulation and expression
Mutations and genetic disorders
Recombinant DNA technology and molecular tools
NCERT-based explanations, diagrams, MCQs, and exam-oriented questions
The content is structured to build strong conceptual foundations , improve problem-solving and analytical skills , and help students perform confidently in school examinations, NEET, and undergraduate assessments .
Develop a clear and integrated understanding of genetics and molecular biology to master one of the most important and scoring areas of modern Biology.
Q. Which of the following is a technique used to amplify DNA?
A.
Gel electrophoresis
B.
Polymerase chain reaction (PCR)
C.
Southern blotting
D.
Sanger sequencing
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Solution
Polymerase chain reaction (PCR) is a widely used technique to amplify specific DNA sequences.
Correct Answer:
B
— Polymerase chain reaction (PCR)
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Q. Which of the following is an example of a mutation?
A.
Color blindness
B.
Height variation
C.
Blood type
D.
All of the above
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Solution
All of the options represent traits that can arise from mutations in genes.
Correct Answer:
D
— All of the above
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Q. Which of the following is NOT a characteristic of Mendelian inheritance?
A.
Segregation of alleles
B.
Independent assortment
C.
Incomplete dominance
D.
Dominance
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Solution
Incomplete dominance is not a characteristic of Mendelian inheritance; it describes a situation where the phenotype is intermediate between the two parental traits.
Correct Answer:
C
— Incomplete dominance
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Q. Which of the following is NOT a component of a nucleotide?
A.
Phosphate group
B.
Nitrogenous base
C.
Amino group
D.
Deoxyribose sugar
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Solution
An amino group is not a component of a nucleotide; nucleotides consist of a phosphate group, a nitrogenous base, and a sugar.
Correct Answer:
C
— Amino group
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Q. Which of the following is NOT a component of the RNA structure?
A.
Ribose sugar
B.
Phosphate group
C.
Deoxyribose sugar
D.
Nitrogenous bases
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Solution
RNA contains ribose sugar, not deoxyribose, which is found in DNA.
Correct Answer:
C
— Deoxyribose sugar
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Q. Which of the following mutations does NOT change the amino acid sequence?
A.
Missense mutation
B.
Nonsense mutation
C.
Silent mutation
D.
Frameshift mutation
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Solution
A silent mutation does not change the amino acid sequence due to the redundancy of the genetic code.
Correct Answer:
C
— Silent mutation
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Q. Which of the following mutations involves a change in a single nucleotide?
A.
Frameshift mutation
B.
Point mutation
C.
Deletion mutation
D.
Duplication mutation
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Solution
A point mutation involves a change in a single nucleotide, which can lead to a different amino acid being incorporated into a protein.
Correct Answer:
B
— Point mutation
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Q. Which of the following mutations is a change in a single nucleotide?
A.
Frameshift mutation
B.
Point mutation
C.
Deletion mutation
D.
Duplication mutation
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Solution
A point mutation is a change in a single nucleotide in the DNA sequence.
Correct Answer:
B
— Point mutation
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Q. Which of the following mutations is likely to have the most severe effect on a protein?
A.
Silent mutation
B.
Missense mutation
C.
Nonsense mutation
D.
Frameshift mutation
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Solution
Frameshift mutations can alter the reading frame of the genetic code, potentially leading to a completely nonfunctional protein.
Correct Answer:
D
— Frameshift mutation
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Q. Which of the following mutations is likely to have the most significant effect on a protein?
A.
Silent mutation
B.
Missense mutation
C.
Nonsense mutation
D.
In-frame mutation
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Solution
A nonsense mutation introduces a premature stop codon, leading to a truncated and often nonfunctional protein, which can have significant effects.
Correct Answer:
C
— Nonsense mutation
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Q. Which of the following mutations is likely to have the most significant impact on protein function?
A.
Silent mutation
B.
Missense mutation
C.
Nonsense mutation
D.
Frameshift mutation
Show solution
Solution
Frameshift mutations can alter the reading frame of the genetic code, potentially leading to completely different and nonfunctional proteins.
Correct Answer:
D
— Frameshift mutation
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Q. Which of the following mutations is most likely to result in a nonfunctional protein?
A.
Silent mutation
B.
Missense mutation
C.
Nonsense mutation
D.
Frameshift mutation
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Solution
A nonsense mutation introduces a premature stop codon, leading to a truncated and often nonfunctional protein.
Correct Answer:
C
— Nonsense mutation
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Q. Which of the following processes directly follows transcription?
A.
Replication
B.
Translation
C.
Splicing
D.
Translocation
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Solution
After transcription, the primary RNA transcript undergoes splicing to remove introns before translation.
Correct Answer:
C
— Splicing
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Q. Which of the following processes involves the synthesis of RNA from a DNA template?
A.
Translation
B.
Replication
C.
Transcription
D.
Mutation
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Solution
Transcription is the process where RNA is synthesized from a DNA template.
Correct Answer:
C
— Transcription
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Q. Which of the following processes occurs first in the central dogma?
A.
Translation
B.
Replication
C.
Transcription
D.
Protein folding
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Solution
Transcription occurs first in the central dogma, where DNA is transcribed into mRNA before translation into protein.
Correct Answer:
C
— Transcription
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Q. Which of the following represents a genotype that is homozygous recessive?
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Solution
The genotype 'aa' indicates that both alleles are recessive, making it homozygous recessive.
Correct Answer:
C
— aa
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Q. Which of the following represents a homozygous genotype?
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Solution
A homozygous genotype consists of two identical alleles, such as AA or aa.
Correct Answer:
B
— AA
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Q. Which of the following represents a homozygous recessive genotype?
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Solution
A homozygous recessive genotype is represented by 'aa', where both alleles are recessive.
Correct Answer:
C
— aa
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Q. Which of the following techniques is used to amplify DNA?
A.
Gel electrophoresis
B.
Polymerase chain reaction (PCR)
C.
Southern blotting
D.
Sanger sequencing
Show solution
Solution
Polymerase chain reaction (PCR) is a technique used to amplify specific DNA sequences, making millions of copies of a particular segment.
Correct Answer:
B
— Polymerase chain reaction (PCR)
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Q. Which of the following techniques is used to introduce recombinant DNA into a host cell?
A.
PCR
B.
Transformation
C.
Gel electrophoresis
D.
Cloning
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Solution
Transformation is the process of introducing recombinant DNA into a host cell, allowing for expression or replication.
Correct Answer:
B
— Transformation
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Q. Which of the following techniques is used to separate DNA fragments by size?
A.
PCR
B.
Gel electrophoresis
C.
Cloning
D.
DNA sequencing
Show solution
Solution
Gel electrophoresis is used to separate DNA fragments based on their size.
Correct Answer:
B
— Gel electrophoresis
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Q. Which process directly follows transcription in the central dogma?
A.
Replication
B.
Translation
C.
Splicing
D.
Translocation
Show solution
Solution
Translation directly follows transcription, where the mRNA is translated into a polypeptide chain at the ribosome.
Correct Answer:
B
— Translation
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Q. Which process involves the conversion of mRNA into a protein?
A.
Replication
B.
Transcription
C.
Translation
D.
Translocation
Show solution
Solution
Translation is the process by which the sequence of nucleotides in mRNA is translated into a sequence of amino acids, forming a protein.
Correct Answer:
C
— Translation
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Q. Which process involves the synthesis of RNA from a DNA template?
A.
Translation
B.
Replication
C.
Transcription
D.
Mutation
Show solution
Solution
Transcription is the process of synthesizing RNA from a DNA template.
Correct Answer:
C
— Transcription
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Q. Which technique is used to amplify a specific DNA segment?
A.
Gel electrophoresis
B.
Polymerase chain reaction (PCR)
C.
DNA sequencing
D.
Cloning
Show solution
Solution
Polymerase chain reaction (PCR) is a technique used to amplify specific DNA segments.
Correct Answer:
B
— Polymerase chain reaction (PCR)
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Q. Which technique is used to amplify DNA segments?
A.
Gel electrophoresis
B.
Polymerase chain reaction (PCR)
C.
DNA sequencing
D.
Cloning
Show solution
Solution
Polymerase chain reaction (PCR) is used to amplify specific DNA segments.
Correct Answer:
B
— Polymerase chain reaction (PCR)
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Q. Which technique is used to amplify DNA?
A.
Gel electrophoresis
B.
Polymerase chain reaction (PCR)
C.
DNA sequencing
D.
Cloning
Show solution
Solution
Polymerase chain reaction (PCR) is a technique used to amplify specific DNA sequences.
Correct Answer:
B
— Polymerase chain reaction (PCR)
Learn More →
Q. Which technique is used to introduce foreign DNA into a host cell?
A.
PCR
B.
Transformation
C.
Gel electrophoresis
D.
Cloning
Show solution
Solution
Transformation is the process of introducing foreign DNA into a host cell, often used in cloning.
Correct Answer:
B
— Transformation
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Q. Which technique is used to separate DNA fragments based on size?
A.
PCR
B.
Gel electrophoresis
C.
Cloning
D.
DNA sequencing
Show solution
Solution
Gel electrophoresis is used to separate DNA fragments according to their size, allowing for analysis and comparison.
Correct Answer:
B
— Gel electrophoresis
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Q. Which technique is used to separate DNA fragments by size?
A.
Gel electrophoresis
B.
PCR
C.
Cloning
D.
Sanger sequencing
Show solution
Solution
Gel electrophoresis is a method used to separate DNA fragments based on their size and charge.
Correct Answer:
A
— Gel electrophoresis
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