Central Dogma: Transcription & Translation - Advanced Concepts

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This section explores the advanced molecular and regulatory aspects of transcription and translation that govern gene expression. It is designed for advanced Class 11–12 students, NEET aspirants aiming for high scores, and undergraduate learners who want deeper conceptual clarity beyond basic mechanisms.

In this section, you will study:

  • Detailed structure and function of RNA polymerases

  • Initiation, elongation, and termination of transcription in prokaryotes and eukaryotes

  • RNA processing including capping, polyadenylation, and splicing

  • Genetic code degeneracy and wobble hypothesis

  • Regulation of translation and role of initiation factors

  • Post-translational modifications and protein targeting

  • Coupling of transcription and translation in prokaryotes

  • NCERT-based advanced interpretations and exam-oriented questions

The content is structured to strengthen conceptual depth, enhance analytical thinking, and prepare students to handle higher-difficulty and reasoning-based questions in NEET and undergraduate-level assessments.

Develop a deeper understanding of transcription and translation by connecting molecular mechanisms with regulation and functional outcomes.

Q. In eukaryotic cells, what modification occurs to pre-mRNA before it becomes mature mRNA?
  • A. Addition of a poly-A tail and 5' cap
  • B. Splicing out of exons
  • C. Replication of DNA
  • D. Translation into protein
Q. What is the function of the ribosome during translation?
  • A. To synthesize RNA
  • B. To provide a site for protein synthesis
  • C. To splice mRNA
  • D. To replicate DNA
Q. What is the role of the 5' cap in mRNA processing?
  • A. To signal the start of translation
  • B. To protect mRNA from degradation
  • C. To facilitate splicing
  • D. To enhance transcription
Q. What is the significance of the promoter region in gene expression?
  • A. It is where RNA polymerase binds to initiate transcription
  • B. It codes for the protein product
  • C. It is involved in splicing of mRNA
  • D. It terminates transcription
Q. Which of the following mutations is likely to have the most severe effect on a protein?
  • A. Silent mutation
  • B. Missense mutation
  • C. Nonsense mutation
  • D. Frameshift mutation
Q. Which type of RNA carries the genetic code from DNA to the ribosome?
  • A. rRNA
  • B. tRNA
  • C. mRNA
  • D. snRNA
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